Why add caffeine USP to Replenix? Research has shown that the addition of caffeine USP to green tea polyphenols actually enhances the antioxidant properties of the already powerful green tea. Conney, et.al. have published widely on the effects of caffeine and the green tea polyphenol Epigallocatechin 3-gallate (EGCG) with regard to inhibition of sunlight-induced skin cancer in humans. The data they present shows very high rates of tumor inhibition. An additional study out of Rutgers University College of Pharmacy found that topical applications of caffeine or EGCG inhibited carcinogenesis and selectively increased apoptosis in UVB-induced tumors in mice. While Clavin Labs in no way makes a cancer prevention claim, we do encourage our customers to review the literature and make their own decisions. How much caffeine is added to Replenix? Clavin Labs works closely with our manufacturer in formulating our skin care products according to reputable research studies for maximum efficacy. In this case, Replenix has the same amount of caffeine that was used in the Rutgers study "Topical Applications of Caffeine or Epigallocatechin Gall ate (EGCG) Inhibit Carcinogenicity and Selectively Increase Palpitates in UVB-Induced Skin Tumors in Mice". Should I be concerned about the stimulant side effects of caffeine? Due to the small surface area being treated, generally the face, hands and neck, it is not expected that the patient will feel any difference at all. Does the caffeine USP in Replenix CF present any skin irritation issues? During the product trials and development no irritation was noted. Caffeine and related compounds ahve a history of use in cosmetics and are not known to be irritatants. Can I use Replenix CF with other skin care regimens? Absolutely, it is compatible with all other products, and reduces the irritation sometimes associated with other treatments such as AHAs, retinoids, hydroquinones or acne products. The use of a high-quality SPF sunscreen and Replenix CF should be encouraged. |
